Induction of Rat Mammary Adenomas with the Respiratory Inhibitory Rotenone1
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چکیده
We have tried the well-characterized respiratory inhibitor rotenone (1) and found it to be consistently tumorigenic in the albino rat. This finding, together with the mitochon dria! characteristics observed in the rotenone-induced tu mors, is reported here. Rotenone tumors represent a class of tumors produced by small amounts of a chemical com pound with a defined biochemical action. Furthermore, the tumorigenicity of rotenone could be of ecological sig nificance,2 because rotenone is at present used as an insec
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